Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise?
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منابع مشابه
Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise?
We tested the effects of swimming training and insulin therapy, either alone or in combination, on the intracellular calcium ([Ca(2+)]i) homeostasis, oxidative stress, and mitochondrial functions in diabetic rat hearts. Male Wistar rats were separated into control, diabetic, or diabetic plus insulin groups. Type 1 diabetes mellitus was induced by streptozotocin (STZ). Insulin-treated groups rec...
متن کاملAttenuation of Ca homeostasis, oxidative stress, and mitochondrial dysfunctions in diabetic rat heart: insulin therapy or aerobic exercise?
Márcia F. da Silva, Antônio J. Natali,* Edson da Silva, Gilton J. Gomes, Bruno G. Teodoro, Daise N. Q. Cunha, Lucas R. Drummond, Filipe R. Drummond, Anselmo G. Moura, Felipe G. Belfort, Alessandro de Oliveira, Izabel R. S. C. Maldonado,* and Luciane C. Alberici* Departments of General Biology and Physical Education, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil; Department of Bas...
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Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and L-carnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats. Materials and Methods: In this experimental s...
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PURPOSE Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats. METHODS 28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was ind...
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The hepatitis C virus (HCV) infection produces several pathological effects in host organism through a wide number of molecular/metabolic pathways. Today it is worldwide accepted that oxidative stress actively participates in HCV pathology, even if the antioxidant therapies adopted until now were scarcely effective. HCV causes oxidative stress by a variety of processes, such as activation of pr...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2015
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00915.2014